Genovior is capably of developing protein process for the products, either new or generic biologics, initiated by clients for clinical application or for filing purposes for commercial productions in a timely fashion and under economical budgeting. Genovior can also efficiently and effectively tech-transfer microbial process, both up-stream and down-stream to our facilities from customers.
Upstream Process Development
- Bioprocess development in scales from shake flask, 5 L fermenter, to 50 L fermenter
- Clone construction for peptides or microbial products
- Media selection, screening, and optimization
- Fed-batch development and feeding strategy optimization
- Fixed angle, tubular centrifuge, and tangential flow filtration system for cell harvest development
- Primary recovery and refolding yield maximization
Downstream Process Development
- Resin selection, screening, and optimization, including ion exchange, hydrophobic interaction, size exclusion, affinity and reverse phase
- Precipitation and extraction development
- Buffer selection, screening, and optimization
- Protein conjugation
- Purification optimization